Prolonged Stupor in Perampanel Overdose and Pharmacokinetic Considerations
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic and pharmacodynamic considerations
in antimalarial dose optimization 2 3 NJ White 4 5 Mahidol-Oxford Tropical Medicine Research Unit, 6 Faculty of Tropical Medicine, Mahidol University, 7 Bangkok, Thailand. 8 9 Centre for Tropical Medicine, Churchill Hospital, 10 Oxford University, Oxford, United Kingdom 11 12 13 14 15 16 17 Correspondence: 18 Prof NJ White 19 Mahidol-Oxford Research Unit, 20 Faculty of Tropical Medicine, 21 Mah...
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PURPOSE This study explored the pharmacodynamic and pharmacokinetic effects of combining perampanel (PER) with commonly co-administered AEDs. METHOD A strong stimulus intensity (three-fold higher than after-discharge threshold) was used to elicit drug-resistant seizures in a rat amygdala kindling model. Vehicle, low-dose PER (0.75 mg/kg), or high-dose PER (1.5mg/kg), in combination with vehic...
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ژورنال
عنوان ژورنال: Journal of Epilepsy Research
سال: 2018
ISSN: 2233-6249,2233-6257
DOI: 10.14581/jer.18014